LPIN1 and LPIN2 catalyze the reaction of the conversion of phosphatidic acid to diacylglyerol.
2.
Phosphatidic acid is a signal molecule and acts to recruit downstream of DAG and vice versa.
3.
Two phosphatidic acid moieties connect with a glycerol backbone in the center to form a dimeric structure.
4.
Then acylglycerol-3-phosphate can be acylated to form a phosphatidic acid ( PA ).
5.
Phosphatidic acids can also be hydrolyzed by lysophosphatidic acid phosphatase, but at a significantly lower rate.
6.
This stops the production of phospholipids and phosphatidic acids to signal the end of a cell's proliferation process.
7.
It has a high affinity for phosphatidic acid and cardiolipin and can be induced by interferon gamma and tumor necrosis factor alpha.
8.
Phosphatidylcholine ( PC )-specific phospholipases D ( PLDs ) catalyze the hydrolysis of PC to produce phosphatidic acid and choline.
9.
Phospholipase D catalyzes the hydrolysis of phosphatidylcholine to form phosphatidic acid ( PA ), releasing the soluble choline headgroup into the cytosol.
10.
The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis.
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